Breaking

Autism-Linked Gene Found to Shape Nerve Connections - Neuroscience News
Dec 02, 2022 2 mins, 14 secs
Neuroscience can involve research from many branches of science including those involving neurology, brain science, neurobiology, psychology, computer science, artificial intelligence, statistics, prosthetics, neuroimaging, engineering, medicine, physics, mathematics, pharmacology, electrophysiology, biology, robotics and technology.

– Neurology research can include information involving brain research, neurological disorders, medicine, brain cancer, peripheral nervous systems, central nervous systems, nerve damage, brain tumors, seizures, neurosurgery, electrophysiology, BMI, brain injuries, paralysis and spinal cord treatments.

Summary: The autism-linked Gabrb3 gene appears to shape the formation of both normal and atypical neural connections in the brain.

A gene linked to autism spectrum disorders plays a critical role in early brain development and may shape the formation of both normal and atypical nerve connections in the brain, according to a new study by Weill Cornell Medicine investigators.

Both conditions involve abnormal behaviors and unusual responses to sensory stimuli, which appear to stem, at least in part, from the formation of atypical connections between neurons in the brain.

program in the laboratory of Natalia De Marco García, an associate professor in the Feil Family Brain and Mind Research Institute at Weill Cornell Medicine.

The gene Gabrb3 encodes part of a critical receptor protein found in inhibitory connections in the brain, which tamp down neuronal activity to maintain order in the nervous system, like police officers directing traffic.

During development, Gabrb3 also appears to help determine how brain connections form.

The preclinical experiments, which Babij performed alongside co-first author Camilo Ferrer, a postdoctoral associate in the De Marco García lab, and others, revealed that mice lacking Gabrb3 fail to form the normal network of connections between neurons in a specific brain region involved in sensory processing.

Theodore Schwartz’s lab at Weill Cornell, the authors showed that the net result of Gabrb3 deletion is an increase in functional connections between the two hemispheres of the brain in the genetically modified mice, compared to those with a functional Gabrb3 gene.

“Basically, what we see is that these neurons are more responsive to sensory stimuli after deletion of this gene,” De Marco García said.

The investigators found a correlation between the spatial distribution of the human GABRB3 gene and atypical nerve connectivity in those with ASD.

“The lower the expression of GABRB3 in specific brain regions, the more atypical nerve connections these regions were likely to contain,” said De Marco García said.

While cautioning that it is impossible to draw direct parallels between the preclinical and human data, De Marco García suggests that both analyses point to a model of neurologic disorders in which alterations in genes such as GABRB3 could drive specific changes in neuronal connection patterns, which in turn lead to abnormal behaviors.

1. NASA’s ‘Mega Moon Rocket’ aced first flight and is ready for crewed Artemis II launch - TechCrunch
Jan 27, 2023 # science 1 min, 3 secs
2. HBO and Sky have put The Last of Us - Episode 1 on YouTube for free | VGC - Video Games Chronicle
Jan 27, 2023 # entertainment 42 secs
3. Academy 'Conducting a Review' After Actress' Shock Oscar Nom - The Daily Beast
Jan 28, 2023 # politics 1 min, 2 secs
4. Mike McCarthy to call plays as Cowboys part ways with Kellen Moore - The Dallas Morning News
Jan 29, 2023 # politics 56 secs
5. Bachelor Nation's Sarah Herron Shares Her Newborn Son Died Hours After Giving Birth - Entertainment Tonight
Feb 02, 2023 # entertainment 40 secs
6. Three or more concussions add up to long-term cognitive problems, study suggests - The Guardian
Jan 31, 2023 # health 1 min, 10 secs
7. Scientists Reveal New Potential Therapeutic Targets for Mental and Neurological Disorders - SciTechDaily
Jan 31, 2023 # health 58 secs
8. ChromeOS will add a new integration for Microsoft 365 for easier use on Chromebooks - Chrome Unboxed
Jan 27, 2023 # technology 52 secs
9. Drake fawns over his son Adonis while attending his mother's 75th birthday celebration - Daily Mail
Jan 30, 2023 # entertainment 51 secs
10. Stranger Things' Finn Wolfhard was 'really proud' when he learned Noah Schnapp came out as gay - Daily Mail
Feb 01, 2023 # entertainment 53 secs
11. Nick Offerman on His Episode of The Last Of Us, Reactions to His Performance & Being Spoiled on Tour - Jimmy Kimmel Live
Feb 02, 2023 # entertainment 7 secs
12. Shrinking: We Speak to Series Co-Creator and Star Jason Segel - GogglerMy
Feb 02, 2023 # entertainment 16 secs
13. Overwatch 2 Will Make Matchmaking and Ranked Suck Less - Kotaku
Jan 30, 2023 # technology 1 min, 3 secs
14. CDC advises against using EzriCare eye drops as it investigates dozens of infections and one death in 11 states - CNN
Feb 01, 2023 # politics 45 secs
15. Google Home app Wifi controls get redesigned devices list [Gallery] - 9to5Google
Jan 29, 2023 # technology 34 secs
16. You Can't Unsee Twitter's 'Useless' But Amazing Animation Facts - Kotaku
Jan 27, 2023 # technology 1 min, 11 secs

RECENT NEWS

SUBSCRIBE

Get monthly updates and free resources.

CONNECT WITH US

© Copyright 2023 365NEWSX - All RIGHTS RESERVED