So when Robin Mansukhani was told it could be done using reawakened immune cells, he was intrigued.
Back in 2018, Mansukhani was introduced to Anil Bhushan, a professor at the University of California, San Francisco, who was working on a way to weaponize invariant Natural Killer T (iNKT) cells against senescent cells to treat type 1 diabetes.While the team is no longer going after diabetes, they published a paper on Monday in Med linking in vivo iNKT cells with clearing senescent cells.
“These cells have long been of interest to people — they just, you know, haven’t really figured out what to do with them or what they really do,” Mansukhani, now CEO, said.“There was something in the senescent cell that said, OK, there’s a footprint here to an immune cell that’s going to talk to this senescent cell and clear it out.
Unlock this story instantly and join 105,100+ biopharma pros reading Endpoints daily — and it's free.Soon after becoming the darling of the VC crew and clearing the bar on a $4 billion valuation, Ginkgo — a synthetic biotech player out to reprogram cells with industrial efficiency — has now struck a deal to go public in the latest leviathan SPAC that sets its pre-money valuation at $15 billion. Unlock this story instantly and join 105,100+ biopharma pros reading Endpoints daily — and it's free.On Tuesday, Appia Bio launched with $52 million in Series A financing led by 8VC and a platform focused on what are called invariant natural killer T cells (iNKT), an extremely rare immune cell the biotech hopes to reengineer to bust malignant tumors through a “best of both worlds” attack plan, the company said