Major races towards championships, both conference and the College Football Playoff, heat up on Saturday as the regular season nears its conclusion.

There's no conference in which separation is potentially greater than the Big Ten, and two of the titans from the East Division in the conference with CFP aspirations are set to square off in a marquee top-10 showdown here in Week 12. .

7 Michigan State going on the road to Columbus to face a No.

4 Ohio State team that's really seemed to find its offensive rhythm of late.

6 Michigan -- a team it defeated this season.

2 Alabama, which can clinch the SEC West title and set up the most anticipated matchup of the 2021 season in the conference title game on Saturday, Dec.

Be sure to stick with CBS Sports throughout the day for college football coverage from the opening kickoff onward.

The first and most important one is that Michigan State is a good football team, so to get nearly three touchdowns with them against an Ohio State team that's struggled to dominate opponents all season long is a hard deal to pass up.

While this one is huge, Ohio State plays Michigan next week.

The Buckeyes have been bad against the spread before the Michigan game, and they have failed to cover the spread a week before Michigan for seven straight seasons (they didn't play last year). Prediction: Michigan State (+19) -- Tom Fornelli.

| ABC, fuboTV (Try for free) -- Utah's only loss in the last two months came against an Oregon State team that is one of only two teams in the conference that averages more yards rushing per game than Utah

Which college football picks can you make with confidence in Week 12, and which College Football Playoff contender will go down hard? Visit SportsLine to see which teams will win and cover the spread -- all from a proven computer model that has returned almost $3,500 in profit over the past five-plus seasons -- and find out