James Toliver Craig, 45, had flown in his mistress, a Texas orthodontist with whom he had exchanged “sexually explicit” emails, to Denver while the mother of his six children was dying in the hospital, allegedly by his own doing, investigators said in the document.

Angela’s condition rapidly deteriorated after she was admitted last Wednesday and she was placed on a ventilator before being declared brain-dead and then taken off life support on Sunday, police said.

The affidavit paints a picture of what led up to the alleged murder — including a troubled marriage, infidelity, financial problems, and even a past incident in which Craig reportedly poisoned Angela.

In early March, when Angela began to exhibit symptoms and first went to the hospital, she told her husband by text she “felt drugged.”

However, another employee accidentally opened it and when the office manager was resealing it, she found “a bio-hazard sticker and what said ‘Potassium Cyanide’ on a circular canister” inside, according to the affidavit.

Aurora Police Department Division Chief Mark Hildebrand called the alleged poisoning “a heinous, complex and calculated murder.”