More than 32,000 people have volunteered to participate in challenge trials for COVID-19 vaccines, which would involve intentional exposure to SARS-CoV-2 in an attempt to speed up vaccine development and availability. .

Diagnostic testing for COVID-19 is critical, yet who, when, and how to test is not always clear.

Physicians in Denmark described the case of a woman with COVID-19 who developed fatal pulmonary fibrosis after acute respiratory distress syndrome (ARDS).

As many as 42% of hospitalized patients with COVID-19 develop ARDS, which is a known cause of pulmonary fibrosis.

"In practice, what this means for clinicians looking after patients with COVID-19, especially those with ARDS, is that they need to be vigilant for the development of pulmonary fibrosis even after mild disease, and there should be a low threshold for repeating CT scans and lung function in patients who have persisting or worsening breathlessness weeks to months after their acute COVID-19," one doctor from London commented.

Critical pediatric COVID-19 is rare, with variable symptoms and generally good outcomes compared with adults, according to preliminary data from the Critical Coronavirus and Kids Epidemiology study. .

The researchers are collecting information from 65 pediatric intensive care units in 18 countries, and in a new paper described initial insights from the first 17 children with severe or critical COVID-19 from 10 pediatric intensive care units in Chile, Colombia, Italy, Spain, and the United States. .

A randomized, controlled clinical trial evaluating the safety and efficacy of the immunomodulator interferon beta-1a in combination with remdesivir in COVID-19 patients has begun, the National Institutes of Health (NIH) announced on Thursday.

The study, also known as the Adaptive COVID-19 Treatment Trial 3, is aiming to enroll more than 1000 hospitalized COVID-19 patients at about 100 sites globally.

In recent COVID-19 news, scientists experimented with a do-it-yourself vaccine, researchers proposed that a compound extracted from seaweed could be a more effective antiviral than remdesivir, and a study suggested that eating cabbage was associated with lower mortality from COVID-19.

Cite this: COVID-19 Update: Vaccine Challenge Trials, Desperate PPE Measures - Medscape - Aug 07, 2020