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Drug slows Alzheimer's but can it make a real difference? - The Associated Press - en Español
Nov 30, 2022 1 min, 20 secs
An experimental Alzheimer’s drug modestly slowed the brain disease’s inevitable worsening — but the anxiously awaited new data leaves unclear how much difference that might make in people’s lives.

Ron Petersen, an Alzheimer’s expert at the Mayo Clinic, said the drug’s effect was “a modest one but I think it’s clinically meaningful” -- because even a few months’ delay in progression could give someone a little more time when they’re functioning independently.

The trial is important because it shows a drug that attacks a sticky protein called amyloid -- considered one of several culprits behind Alzheimer’s -- can delay disease progression, said Maria Carrillo, chief science officer for the Alzheimer’s Association.

Eisai said Tuesday the deaths can’t be attributed to the Alzheimer’s drug.

But Mayo’s Petersen said if lecanemab is approved for use in the U.S., he’d avoid prescribing it to people on blood thinners at least initially.

And Thambisetty said the death reports raise concern about how the drug may be tolerated outside of research studies “where patients are likely to be sicker and have multiple other medical conditions.”.

If the FDA approves lecanemab, patients and their families will need a voice in deciding whether it’s worth the hassle of IV infusions and the risk of side effects for the chance of at least some delay in progression, Petersen said.

“I don’t think we’re going to stop the disease in its tracks” with just amyloid-targeting drugs, he added, saying it will take a combination of medications that target additional Alzheimer’s culprits.

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