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FDA approves 'glowing tumor' drug to help surgeons identify ovarian cancer cells - Fox News
Dec 01, 2021 1 min, 42 secs

Cytalux (pafolacianince), a drug that binds to ovarian cancer tissue and glows when exposed to fluorescent light, has been approved by the U.S.

"While many surgeries result in complete resection of all cancer tissue, a substantial fraction unfortunately leave buried or concealed tumor tissue behind, often resulting in recurrence of the cancer and sometimes even death," Low told Fox News.

"Cancer cells have an enormous appetite for this vitamin," Low said in the release, "and we exploited their greed for folic acid by attaching a fluorescent dye to it.".

Sunil Singhal, along with colleagues at the Center for Precision Surgery in the Abramson Cancer Center at the University of Pennsylvania in partnership with On Target Laboratories, led one of the largest clinical trial sites in the country for Cytalux, according to the spokesperson.

"By using a fluorescent dye that binds to cancer cells, making them glow during surgery, surgeons can identify and resect as much of a patient’s tumors as possible and improve prognosis," Singhal, director of the Center for Precision Surgery at the Abramson Cancer Center at the University of Pennsylvania said in release. .

The university researchers said this new technology provides surgeons with a guide that goes beyond what is seen with the naked eye or touch, especially when the lesions are small, according to the release.

"Lighting up cancer, which helps to identify lesions that may be difficult to find — especially in the presence of scar tissue or other organ damage — enables more complete identification and surgical removal of cancer that could have otherwise been missed," Janos L.

Tanyi, who is also an associate professor of obstetrics and gynecology in the Perelman School of Medicine at the university also said that this new FDA approval will offer promise for improved outcomes in patients with ovarian cancer, who face a high risk of recurrence after initial treatment

The investigators said in the release that only 20% of ovarian cancers are detected early because it is either asymptomatic or the symptoms mimic common gastrointestinal, bladder or bowel issues

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