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Israeli find shown to combat antibiotic resistance by ‘pricking bacteria to death’ - The Times of Israel
Jan 27, 2023 54 secs
Israeli scientists have developed a substance that overcomes antibiotic resistance by “pricking bacteria to death,” researchers at Ben Gurion University told the Times of Israel on Friday, in a breakthrough that could help combat a major threat to global health.

“Most antibiotics in use today work by affecting functions inside the bacteria, but our solution attacks the outside of the pathogen instead,” Nofar Yehuda, one of the scholars, told The Times of Israel.

She described the process in more scientific language in peer-reviewed research, authored together with Ben Gurion professors Shoshana Arad, Ariel Kushmaro and Levi Ghebe and published in December.

They wrote that lab research results “clearly point to a direct effect of the spikes — via membrane disruption —on the bacteria, which culminated in cell death.”

Ben Gurion University’s technology transfer company has patented the substance and hopes to commercialize it.

A study by the Lancet medical journal estimated that in 2019, more than 1.2 million people died of antibiotic-resistant bacterial infections and noting that this was more deaths than those caused by leading global health threats like HIV/AIDS or malaria.

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