With millions of Americans on the move Wednesday, health experts worry what is usually one of the country's biggest nights for travel may also become one of its most dangerous.

Despite blunt warnings from public health officials pleading for people to stay home this Thanksgiving, millions are hitting the skies and roads anyway. .

Romeo Garcio left Maryland on Wednesday afternoon for his parents' home in Greenville, North Carolina.

"The holidays are really the only times where I could be able to see my family," he said.

New York City police are setting up checkpoints at bridges and tunnels, and Maryland state troopers are checking if bars and restaurants are following the rules.

A stay-at-home advisory is now in place in Pennsylvania, and the state has ordered bars, restaurants and private catered events to stop alcohol sales for on-site consumption starting at 5 p.m.

In Los Angeles County, dining at restaurants, breweries, wineries and bars will be restricted starting Wednesday.

"Please don't be like my family and ignore the CDC guidelines," one of the family members said in a video.