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Revolutionary cancer treatment wakes up immune system to destroy tumors - Study Finds
Oct 20, 2021 57 secs
They are delivered with a payload of medications that activate the immune system’s T cells.

The injured cancer cells appear to act as a distress signal that spurs them into action.

“When you create cells that have DNA damage but are not killed, under certain conditions those live, injured cells can send a signal that awakens the immune system,” says senior author Professor Michael Yaffe in a university release.

Adding chemotherapy drugs helped injured cells send signals that attract the immune system’s attention.

“We showed that if you treated tumor cells in a dish, when you injected them back directly into the tumor and gave checkpoint blockade inhibitors, the live, injured cells were the ones that reawaken the immune system.”.

The chemicals send out distress signals that provoke T cells to destroy injured cells and any other tumor cells nearby.

However, this was ineffective because the chemotherapy drugs also harmed T cells and other immune cells near the tumor.

Also, injecting the injured cells without checkpoint blockade inhibitors had little benefit.

The researchers are also further investigating exactly how the injured tumor cells stimulate such a strong T cell response

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