The rest of his response focused on his opposition to vaccine mandates as governor, saying the Covid-19 vaccine and subsequent booster shots should be "people's individual decision."

On Tuesday, DeSantis declined to mention the word "vaccine" once in a 30-minute State of the State speech.

His office quietly confirmed in April that DeSantis had received a single dose of the Johnson & Johnson vaccine, and his communications team has refused to say whether he followed up with a booster, insisting that was private medical information.

Instead of publicly encouraging vaccination and boosters, DeSantis has focused on alternative treatment like monoclonal antibodies while opposing federal vaccination mandates.

In a statement to CNN on Wednesday, DeSantis spokeswoman Christina Pushaw claimed it wasn't clear that Trump was referring to the Florida Republican in his criticism.

Governor DeSantis has always been clear about his position on Covid-19 vaccination and boosters: the shots should be available to all but mandated for none, and the choice to get a vaccine or booster is an individual's private medical decision," Pushaw said.