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Reproductive genome from the laboratory

Reproductive genome from the laboratory

Reproductive genome from the laboratory
Feb 18, 2020 45 secs

Proteins are made of amino acids.

Modular structure of the construction manual

Specifically, the researchers have optimized an in vitro expression system that synthesizes proteins based on a DNA blueprint.

Due to several improvements, the in vitro expression system is now able to synthesize proteins, known as DNA polymerases, very efficiently.

The largest modular genome reproduced by the researchers in the study consists of more than 116,000 base pairs, reaching the genome length of very simply cells.

Regeneration of proteins

Apart from encoding polymerases that are important for DNA replication, the artificial genome contains blueprints for further proteins, such as 30 translation factors originating from the bacterium Escherischia coli.

Translation factors are important for the translation of the DNA blueprint into the respective proteins.

In order to show that the new in vitro expression system is not only able to reproduce DNA, but is also able to produce its own translation factors, the researchers used mass spectrometry.

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