Dyslipidemia Is Associated With Asthma Exacerbations and Uncontrolled Asthma - Pulmonology Advisor

Dyslipidemia is a risk factor for uncontrolled asthma and is an independent risk factor for future asthma exacerbations, according to study findings published in Journal of Allergy and Clinical Immunology: In Practice.

The study enrolled adult participants with stable asthma from a hospital in Sichuan, China, from June 2015 to August 2019.

Dyslipidemia was a risk factor for uncontrolled asthma (adjusted odds ratio [OR adj]=1.808; 95% CI, 1.167-2.801) after adjustment for age, sex, body mass index (BMI), inhaled corticosteroids (ICS) dose, smoking, hypertension, and fasting blood glucose.

In the 12-month follow-up, dyslipidemia was associated with an increased frequency of severe AEs (adjusted rate ratio [RR adj]=1.910; 95% CI, 1.075-3.395) and moderate-to-severe AEs (RR adj= 1.435; 95% CI, 1.019-2.019), according to multivariable negative binomial regression models after adjustment.

“These findings highlight the importance of considering dyslipidemia as an ‘extrapulmonary trait’ in asthma management,” stated the study authors.

In patients with asthma studied, pulmonary function measures were significantly worse among those who had dyslipidemia.