At this point, Grey’s Anatomy fans know they’re in danger when “Chasing Cars” by Snow Patrol starts playing.

Later, Grey’s Anatomy brought back “Chasing Cars” in the season 7 musical episode — titled “Song Beneath the Song.” Fans were terrified when Callie Torres (Sara Ramirez) suffered a car accident and the staff suddenly started singing.

Grey’s Anatomy fans didn’t understand the impact of The Fray’s “How to Save a Life” when it first played in the second season.

But the musical episode turned “How to Save a Life” into so much more.

And while “Chasing Cars” opened the Grey’s Anatomy episode, “How to Save a Life” closed. .

The Grey’s Anatomy Season 10 finale — titled “Fear (of the Unknown)” — was truly the end of an era!