Oct 20, 2021 3 mins, 5 secs

Hospital staffers diagnosed Dante with multisystem inflammatory syndrome in children, or MIS-C, a rare but life-threatening complication of Covid-19 in which a hyperactive immune system attacks a child’s body.

children diagnosed with Covid have developed MIS-C.

About 80 percent of MIS-C patients are treated in intensive care units, 20 percent require mechanical ventilation, and 46 have died.

Throughout the pandemic, MIS-C has followed a predictable pattern, sending waves of children to the hospital about a month after a Covid surge.

At Medical University of South Carolina Shawn Jenkins Children’s Hospital, for example, doctors last month treated 37 children with Covid and nine with MIS-C — the highest monthly totals since the pandemic began.

Although most children who develop MIS-C had been healthy, 80 percent develop heart complications.

Some patients develop heart rhythm abnormalities or aneurysms, in which artery walls balloon out and threaten to burst.

Adults also can develop a post-Covid inflammatory syndrome called MIS-A; it’s even rarer than MIS-C, with a mortality rate seven times as high as that seen in children.

Although MIS-C is new, doctors can treat it with decades-old therapies used for Kawasaki disease, a pediatric syndrome that also causes systemic inflammation?

Chou acknowledges that her study — which found genetic variants in just 17 percent of patients — doesn’t solve the puzzle.

Most children with MIS-C test negative for Covid, suggesting that the body has already cleared the novel coronavirus from the nose and upper airways.

That led doctors to assume that MIS-C was a “postinfectious” disease, developing after “the virus has completely gone away,” said Dr.

Lael Yonker noticed that children with MIS-C are far more likely to develop gastrointestinal symptoms — such as stomach pain, diarrhea and vomiting — than the breathing problems often seen in acute Covid.

In some children with MIS-C, abdominal pain has been so severe that doctors misdiagnosed them with appendicitis; some actually underwent surgery before their doctors realized the true source of their pain.

Yonker, a pediatric pulmonologist at Boston’s MassGeneral Hospital for Children, recently found evidence that the source of those symptoms could be the coronavirus, which can survive in the gut for weeks after it disappears from the nasal passages.

The body breaks down viral RNA very quickly, Chou said, so it’s unlikely that genetic material from a Covid infection would still be found in a child’s stool a month later.

Although the first doctors to treat MIS-C compared it to Kawasaki disease — which also causes red eyes, rashes and high fevers — Arditi said MIS-C more closely resembles toxic shock syndrome, a life-threatening condition caused when particular types of strep or staph bacteria release toxins into the blood.

Toxins released by the bacteria can trigger a massive overreaction from key immune system fighters called T cells, which coordinate the immune system’s response, said Arditi, the director of the pediatric infectious diseases division at Cedars-Sinai Medical Center.

In a typical response to a foreign substance — known as an antigen — the immune system activates only about 0.01 percent of all T cells, Arditi said.

That allows superantigens to activate 20 percent to 30 percent of T cells at once, generating a dangerous swarm of white blood cells and inflammatory proteins called cytokines, Arditi said.

Although multiple studies have found that children with MIS-C have fewer total T cells than normal, Arditi’s team has found an explosive increase in a subtype of T cells capable of interacting with a superantigen.

“He’s back to all these activities,” said DeMaino, noting that Dante’s doctors rechecked his heart six months after his illness and will check again after a year.

Although children who survive Kawasaki disease have a higher risk of long-term heart problems, doctors don’t know how MIS-C survivors will fare

1. 'America First' Policy Group Backs Navy SEALs Fighting Vaccine Mandate
Nov 24, 2021 # breaking 1 min, 2 secs
2. Democrats aren't alone in the cannabis game anymore - Politico
Nov 21, 2021 # politics 2 mins, 5 secs
3. 'It's Coming': N.Y. Gov. Kathy Hochul Issues Omicron Warning, Declares State of Emergency - Newsweek
Nov 27, 2021 # politics 34 secs
4. Five things I hate about Windows 11 - Neowin
Nov 21, 2021 # technology 5 mins, 27 secs
5. Dell XPS 13 now just $650 in unbeatable Black Friday deal - Creative Bloq
Nov 21, 2021 # technology 38 secs
6. Chris Daughtry's wife clears up 'homicide' rumors about daughter's death - Fox News
Nov 20, 2021 # entertainment 58 secs
7. Lin-Manuel Miranda on the "dirty secret" hidden in Tick, Tick... Boom! - BBC News
Nov 21, 2021 # entertainment 3 mins, 3 secs
8. Call of Duty: Vanguard Disables Secrets of the Pacific After 'Widespread Crashes' - IGN
Nov 25, 2021 # technology 28 secs
9. Tiffany is selling its most expensive piece of jewelry ever - CNN
Nov 22, 2021 # entertainment 31 secs
10. Hair loss treatment: Three powerful herbs to help combat loss and promote hair regrowth - Daily Express
Nov 24, 2021 # health 33 secs
11. Star Trek: Discovery is tearing the streaming world apart - Ars Technica
Nov 21, 2021 # entertainment 2 mins, 20 secs
12. New Covid strain may be 'more infectious than Delta variant' - symptoms to expect - Daily Express
Nov 20, 2021 # health 33 secs
13. Diabetes warning signs - the 5 early symptoms you shouldn't ignore - Daily Express
Nov 24, 2021 # health 45 secs
14. New COVID-19 Vaccine Offering Long-Lasting Immunity Passes First Human Trial - IFLScience
Nov 23, 2021 # health 43 secs
15. Austria Imposes Lockdown and Mandatory Vaccination Amid Covid Surge - The New York Times
Nov 22, 2021 # politics 1 min, 47 secs
16. NFL Week 11 fantasy football inactives watch - Who's in and who's out? - ESPN
Nov 21, 2021 # politics 56 secs

SUBSCRIBE

Get monthly updates and free resources.

CONNECT WITH US

© Copyright 2021 365NEWSX - All RIGHTS RESERVED